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Furthermore, in the livers of rats with diabetes, there was an accelerated rate of MT expression and cytoplasmic MT turnover, whereas in the kidneys, only the expression rate of MTs was increased, but not their cytoplasmic turnover [123, 130]

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Released glutamate binds to both AMPA and NMDA receptors, and sodium influx occurs through open AMPA channels, which depolarizes the cell enough to expel the magnesium ion and allow ion flow through the NMDA receptors