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ATF4 knockdown confirmed that amino acid metabolism activation is ATF4-dependent downstream of IFN- signalling

Nitric Oxide Synthase (eNOS/iNOS) Pathway Regulation Stimulates NO production through eNOS/iNOS activation : BPC-157 upregulates nitric oxide synthesis in vascular tissue and restores endothelial homeostasis, as shown in ischemic and inflammatory models 3,4

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Cell culture, Oil-Red-O staining and ELISA HepG2 and BRL cells were cultured in Dulbeccos modified Eagles medium (DMEM, Gibco, CHN) with 10% fetal bovine serum (FBS, BI, USA) and 1% double antibody (penicillin/streptomycin, Gibco, CHN) at 37C under 5% CO 2 , respectively