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Methylmercury is designated as a "priority hazardous substance" according to the Directive on Environmental Quality Standards (Directive 2013/39/EU)

Future research should prioritize the development of receptor-selective modulators with proven long-term efficacy, capitalizing on astrocyte-specific biology to optimize neuroprotective therapeutic outcomes

Therefore, cellular availability of GSH through glutathione synthesis is a critical determinant of sensitivity to ferroptosis
