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Originally characterized at the University of Florida by the Stephen ORahilly and Robert Kraft groups, the compound has been studied in preclinical research for body composition, adipose tissue lipolysis, glucose homeostasis, skeletal muscle aging, and metabolic disease endpoints

doi: 10.1096/fj.10-171579 60 ProvenzanoPPAlejandro-OsorioALGrorudKWMartinezDAVailasACGrindelandREet al

IGFALS gene dosage effects on serum IGF-I and glucose metabolism, body composition, bone growth in length and width, and the pharmacokinetics of recombinant human IGF-I administration
