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doi: 10.1007/s10637-013-0032-y 122 KimSTLeeJLeeSJParkSHJungSHParkYSet al

When ERK is phosphorylated, it translocates to the nucleus and activates transcription factors like CREB (cAMP response element-binding protein), which in turn drives the expression of genes responsible for synaptic plasticity and memory formation

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