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Furthermore, for specific compounds, additional key mechanisms such as Fas-mediated signal transduction, loss of cellular redox homeostasis, ATP depletion, changes in ion channels, and activation of kinases and caspases, among others, have been highlighted
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This convergent signaling produces amplified responses
Increased GSH levels and GCLC transcription and mRNA levels (GCLM expression was unchanged) also occur in human hepatocellular carcinoma (HCC) [26]
