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Early application of sildenafil citrate reduced the apoptosis rate of skeletal muscle cells by decreasing caspase-3 expression in a rat model of hind limb ischemia, reducing skeletal muscle cell damage caused by IRI and thus protecting against skeletal muscle LL-IRIrelated damage (Armstrong et al., 2013)

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Proc Nat Acad Sci USA 110:58125817 Dat J, Vandenabeele S, Vranova E, Van Montagu M, Inze D, Van Breusegem F (2000) Dual action of the active oxygen species during plant stress responses

Intermittent fasting, a possible priming tool for host defense against SARS-CoV-2 infection: crosstalk among calorie restriction, autophagy and immune response
