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These harmful effects include temporary or permanent dose-dependent changes in normal semen parameters, changes in testis biochemical and structural characteristics, and apoptosis-related gene expression and testosterone level, which finally result in spermatogenesis disorders and male infertility (34)

( 10.1016/j.nutres.2020.04.002) [DOI] [PubMed] [Google Scholar] 48

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Immediate release clonidine and guanfacine have limited use as they are rapidly absorbed and cleared from the body and have negative side effects
