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Description
Another study identified potential inhibitors through in silico screening, discovering several chemotypes that inhibited NAPRT at micromolar concentrations
However accumulated evidence now clearly suggests that PGHS-2 is also constitutively expressed in a number of tissues including brain, gut, lung, thymus and kidney wherein it produces prostanoids [97]
It occurs through a complex molecular process as detailed in previous review articles [20]
Therefore, targeting eIF5A hypusination by inhibiting the glutamine-derived aspartate-mediated polyamine pathway is a promising therapeutic approach for liver cancer
