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The HHS announcement was made on February 27, 2026, but the formal reclassification has not yet been published in the Federal Register

Additional information Address correspondence to: Nancy Foldvary-Schaefer, DO, MS, Cleveland Clinic Sleep Disorders Center, 9500 Euclid Avenue, S73, Cleveland, OH 44195

These observations underscore the potential link between heightened oxidative stress and the pathogenesis of hypertension ( + holds promise as a therapeutic target for blood pressure regulation

Further analysis of aged mice testes after FOXO4-DRI treatment revealed a reduction in interstitial SA--gal activity, along with decreased levels of senescence-associated proteins p53, p21, and p16