homocysteine and glutathione peroxidase-1 GPX1 - an overview N-Acetyl-Cysteine supplementation lowers high homocysteine
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Despite having an up-regulated basal antioxidant response, STIM1-deficient mouse embryonic fibroblasts experience an imbalance of ROS production and detoxification upon addition of exogenous oxidants (101)

The reason for the increase in each case was not clear
