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Consistent with these findings, our data shows that A 40 oligomers can increase MMP-2 activity in stimulated astrocytes and correlated with increased oxidative stress, inflammation and reduced cell viability

It is vital to note that deficiencies in folic acid, vitamin B12, and vitamin B6 levels have also been linked to both elevated homocysteine and uric acid 19 levels

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However, more recent studies assessing the role of ferrous iron in the pathophysiology first in vitro [74, 75] and then in vivo [76, 77] provided evidence that after a toxic dose of APAP ferrous iron derived from lysosomes is taken up into mitochondria through a Ca 2+ uniporter and facilitates the MPTP opening and cell death