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Description
IGF-1 then circulates to target organs, such as bones and cartilage, acting in an endocrine manner

Regulation of oxygen homeostasis by hypoxia-inducible factor 1

Reactive oxygenated/nitrogenated species are represented by superoxide anion radical, hydroxyl, alkoxyl and lipid peroxyl radicals, nitric oxide and peroxynitrite

The strongest skin evidence: Watanabe et al
