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Safety profile Cardiorenal effects Slight increases in heart rate have been reported with the GLP-1 RAs in certain populations, 60 but the cardiac benefits of using these drugs have been widely investigated

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1 Accordingly, it is practical to determine whether a child presenting with unexplained growth retardation has IGF-I deficiency, the consequence of which is short stature

The BBB is constructed by specialized brain microvascular endothelial cells joined by tight junctions and supported by pericytes, astrocytic end-feet, and the basement membrane, collectively constituting the neurovascular unit (Kaya and Ahishali, 2021)