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A higher resistin level in the symptomatic than in the asymptomatic AIP patients and its positive correlation with leptin levels may indicate that inflammation, adipokines, and hormones affecting insulin resistance may be involved in higher disease activity [10]

SIRT1 promotes BDNF and TrkB expression by enhancing the transactivator PGC-1 and FNDC5 in the SIRT1BDNFTrkB pathway [20, 42]

Such a high level highlights its importance, especially when considering the metabolic activity required for its production

Currently, nanodrug delivery platforms (313), microbubble-enhanced focused ultrasound (MB-FUS) (314) and magnetic resonance-guided focused ultrasound (MRg-FUS) (315) are three promising approaches to break through the BBB