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Description
During sperm maturation, sperm transition proteins (TNP1 and TNP2) replaces the majority of the histone proteins of the spermatids, followed by the deposition of highly basic protamines (PRM1 and PRM2) in elongated spermatids and spermatozoa (Jambor et al., 2017)
36 38 39 However, MMA was normal in 52% of individuals with holoTC concentrations below 20 pmol/L, the latter being indicative of deficiency
Human safety data remain limited, and the complete pharmacological and toxicological profile has not been established
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