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In addition to zinc, pro-inflammatory cytokines are known inducers for A20 in macrophages, possibly representing a feedback-mechanism to prevent hyperinflammatory reactions [181]

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This review synthesizes current knowledge on HT's epidemiology, pathogenesis, and recent therapeutic advances, highlighting the complex interplay of genetic, environmental, and immunological factors that contribute to the disease's progression and management

Selected Data 1) This study performed by Richie et al employed a randomized, double-blinded, placebo-controlled design to investigate the long-term effects of oral glutathione (GSH) supplementation on body stores of GSH in healthy adults