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However, at 144 hpf, thyroid tissue appeared enlarged in around 55% (170/312) of the nrf2a crispants compared with their adamtsl2 crispants and noninjected siblings (Fig S1IL)

10.1007/s10787-017-0309-4 24 JingL.LiL.ZhaoJ.ZhaoJ.SunZ.PengS
Kim JY, Kanai Y, Chairoungdua A, et al
But the same property that makes it useful in culture is what makes any extrapolation to human physiology fraught: broad, persistent activation of a receptor that regulates growth, metabolism, and cell survival across virtually every tissue is a fundamentally different proposition from a self-limiting local pulse
