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This can either be detoxified by the action of glutathione peroxidase, or go on to form the hydroxyl radical, which can damage a range of biomolecules, including DNA, proteins, and lipids (37)
doi: 10.1016/j.jep.2020.112876 9
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In human embryos, just prior to and during the second half of the pronuclear stage and before entering the first mitotic division, demethylated paternal DNA is immediately re-methylated, together with de novo H3-K9 tri-methylation [10]
