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FOXO4-DRI + GHK-Cu Supports tissue regeneration following senolytic clearance in aging skin models

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Res, resveratrol;CCl 4 ,carbon tetrachloride;TIME,carbon tetrachloride;TME,tumor microenvironment;CAFs,cancer-associated fibroblasts;MMPs,matrix metalloproteinases;PQ,paraquat;OX,oxaliplatin;PTHrP,peptide parathyroid hormone-related protein;BMP-7,bone morphogenic protein-7;EndMT,endothelial-to-mesenchymal transition;ADMA,asymmetric dimethylarginine;DDAH1,dimethylaminohydrolase-1;NO,nitric oxide;NOS,nitric oxide synthase;CP,cisplatin;ATO,arsenic trioxide;PD,peritoneal dialysis;ESRD,end-stage renal disease;PGE2,prostaglandin E2;PTGER2,prostaglandin E receptor 2;IPF,idiopathic pulmonary fibrosis;PVR,proliferative vitroretinopathy;RPE,retinal pigment epithelial;EGCG,epigallocatechin gallate;MS,multiple sclerosis;CNS,central nervous system;SCI,spinal cord injury;LIDD,lumbar intervertebral disc degeneration;MH 2 ,MAD homolog 2;SARA,Smad anchor for receptor activation,CNs,curcumin-nanoparticles;RA,rheumatoid arthritis;DCM,diabetic cardiomyopathy;DMI,DM type I,DMII,DM type II;JAK/STAT,Janus kinase/signal transducer and activator of transcription;VVC,vulvovaginal candidiasis;OSCC,oral squamous cell carcinoma;OSMF,oral submucous fibrosis