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doi: 10.1093/geront/gnv130

Data Availability The authors declare that all of the data included in this review are available within the paper and/or are openly available in the Natural Product-Drug Interaction Research (NaPDI) Center Database ( Abbreviations AUC area under the concentration versus time curve DEA US Drug Enforcement Administration FDA US Food and Drug Administration F oral absolute oral bioavailability hCES human carboxylesterase HIM human intestinal microsome HLM human liver microsome K I time-dependent inhibition constant K i reversible inhibition constant k inact maximum rate of inactivation LCMS liquid chromatographymass spectrometry P450 cytochrome P450 PBPK physiologically based pharmacokinetic P-gp P-glycoprotein UGT UDP-glucuronosyltransferase Authorship Contributions Performed data analysis: Tanna

In vivo studies have identified several microbiota associated with TMA/TMAO generation, including Clostridium hathewayi , Providencia alcalifaciens , Escherichia fergusonii and Providencia rustigiani (Romano et al., 2015)