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and Shai, Y., Biopolymers , 1998, vol
Notably, the selective uptake of cystine (an oxidized dimer of cysteine), rather than methionine, as a precursor for cysteine and subsequently GSH biosynthesis imposes a further metabolic constraint: the reduction of cystine to cysteine requires NADPH, the supply of which becomes critical for GSH biosynthesis (see Supplementary Fig
J Clin Investig
Biol Pharm Bull 32, 14471452 (2009)
