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4 Current challenges and prospects 4.1 Therapeutic targeting potential of TGF- 4.1.1 TGF- downstream effectors The therapeutic targeting of TGF- and its downstream effectors, particularly the Smad proteins, presents a promising avenue in fibrosis treatment

Inequalities in dementia incidence between six racial and ethnic groups over 14 years

Studies examining fibroblast and endothelial cell systems show increased phosphorylation of focal adhesion kinase and paxillin, two proteins central to cytoskeletal organization and cell adhesion signaling

Improvements are typically discussed over days to weeks rather than hours