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Without adequate glutathione to neutralize ROS, superoxide radicals collide with and damage the mitochondria's inner membrane (specifically a lipid called cardiolipin) and the mitochondrial DNA itself

(2019) Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo , PLoS One , 14 , 0225931, doi: Louandre, C., Marcq, I., Bouhlal, H., Lachaier, E., Godin, C., Saidak, Z., Francois, C., Chatelain, D., Debuysscher, V., Barbare, J.-C., Chauffert, B., and Galmiche, A

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