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Consistent with this postulate, we observed the greater increase in pSer-IRS-1 in women with stronger severity of depressive symptoms independently of use of psychotropic medications

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Moreover, it plays an immune negative regulatory role in chronic hepatitis B virus (HBA) infection by preventing the formation of germinal centers (GCs), reducing the antiviral activity of GC-related immune cells and enhancing the function of immunosuppressive cells [227]