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[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Fracchiolla D, Chang C, Hurley JH, Martens S A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy

These effects occur despite BPC-157 not directly increasing VEGF-A expression, suggesting the peptide works primarily through receptor sensitization rather than ligand upregulation

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This increase was only present in those who complained of side effects
