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However, MT-II is not approved for any medical use in the UK and carries significant safety concerns
The data is striking: in a Phase 2 trial published in the New England Journal of Medicine, the highest doses produced an average ~24% body-weight reduction at 11 months more than any currently approved weight-loss drug (American Diabetes Association)

Most evidence comes from rodent studies and user reports , not large clinical trials
Science 283 , 14881493 (1999)