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Damaged dopaminergic neurons release matrix metalloproteinase 3, -synuclein, and neuromelanin that superactivated microglia, inducing reactive microgliosis, enhancing of the neurotoxicity-related mediators, such ROS (Figure 3)

Duan, Y

These agents include 2-difluoromethyl ornithine (DMFO), an inhibitor of ornithine decarboxylase and methylglyoxal bis(guanylhydrazone) (MGBG) and 4-amidinoindydrazone-1-(SAM486A), both of which are competitive inhibitors of S-adenosylmethionine decarboxylase
