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Praa C, Rosa SC, Sevin E, Cecchelli R, Dehouck MP, Ferreira LS
GGT1 drives GSH catabolism and survival Several enzymes have GGT activity 38 , and GGT1 is the most catalytically active isoform 39
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Nonetheless, to date the only FDA- and EMA-approved NRF2 activator for the treatment of relapsing-remitting MS and psoriasis is DMF, and its therapeutic potential in ALS patients in terms of efficacy, safety and tolerability, is now being evaluated in a phase-II clinical trial [313]
