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Brown et al., 2006
The comprehensive metabolic profile was reviewed by physicians and compared to known reference ranges
This suggests that extrapolation of pharmacokinetic studies from laboratory animals to humans is of limited validity and should always be done with caution
From a mechanistic perspective, these outcomes are mediated by multi-system endocrine adaptations, including suppression of the HPG axis, alterations in insulin and glucose-regulating hormones, reduced triiodothyronine (T3), elevated cortisol, and disruptions in growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signaling [92]
