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Retatrutide represents a newer option that adds glucagon receptor agonism to GLP-1 and GIP activation, creating a triple agonist
Higher (10 g/kg) dosage was effective either after a single or daily regimen, whereas lower (10 ng/kg) dosage, previously ineffective given as a single application, becomes efficacious when applied as a daily regimen
The initial dosing protocol starts with tirzepatide 2.5 mg weekly plus cagrilintide 0.3 mg weekly, with gradual escalation over several weeks to minimize side effects
