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Y-27,632 is a competitive inhibitor of both Rho-associated protein kinase ROCK1 and ROCK2 (serine-threonine kinases) that competes with ATP in binding the catalytic binding sites of these kinases and thereby interferes with membrane protrusion and vesicle shedding through suppressed activity on LIM kinase and myosin light chain (MLC) 9

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People with Graves, its not as common to have hypo symptoms, but as I mentioned, some people with Graves will gain weight or have coldness or other hypo symptoms