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Evidence from studies in vivo suggests that androgen deficiency is closely associated with decreases in ATP synthesis and the activity of complexes I and III in the hippocampus and substantia nigra of castrated male rats (84), which was improved by exogenous testosterone supplementation (122)

While earlier research suggested few significant distinctions, more recent findings indicate that females may exhibit more severe mood disorders and anxiety, and are often diagnosed later due to subtler symptom profiles and higher camouflaging abilities (Dellapiazza et al., 2022
