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Receptor Binding: Specific CNS Binding Sites Tritium-labelled Semax binding studies in rat basal forebrain have identified high-affinity, specific CNS binding sites with a KD of 2.4 1.0 nM and a BMAX of 33.5 7.9 fmol/mg protein pharmacological parameters consistent with a specifically acting compound at dedicated receptor sites rather than non-specific membrane interactions