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Isotretinoin Isotretinoin: Examination and Clinical Applications Overview Isotretinoin is a systemic retinoid medication derived from vitamin A, used primarily to treat severe or refractory acne, but with broader implications for epithelialcell differentiation, sebum regulation, and inflammatorysignaling pathways

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Diselenide bonds (Se-Se), formed by substituting cysteine residues with selenocysteine (Sec), have emerged as promising disulfide surrogates due to their unique redox properties and structural similarity to disulfide bonds (Mousa et al., 2017