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J.ZhangY.ThijssenV.BuijsN.GaoY.MateuszukL.et al (2021)

36,37 A disruption in normal microbial balance affects immune function, inflammatory signaling, and even transmission of pain signals

Rather than addressing just one aspect of melasma, this approach combines: Deep tissue repair through mesotherapy injections Surface treatment with specialized anti-melanin agents Barrier restoration techniques to optimize skin health Metabolic enhancement to improve the skins natural processes This multi-dimensional strategy targets melasma at every levelfrom the deepest layers where inflammation begins to the surface where pigmentation appears

Pasquel, A., Meireles, M.A.A., Marques, M.O.M., & Petenate, A.J