oral glutathione bioavailability limited Frontiers Bioavailability Study of an Innovative

Due to its unique biochemical function of directly reducing lipid peroxides and blocking the oxidative chain reaction on cell membranes, GPX4 is often regarded as the central barrier or gatekeeping enzyme in the ferroptosis response

For example, multiple studies have shown that the levels of ferritin in the CSF of patients with AD are elevated and this increase is associated with faster rates of cognitive decline and brain atrophy, suggesting that CSF ferritin levels could be a valuable prognostic biomarker (77,78)

doi: 10.1007/s12640-018-9966-3

To address this, we performed pathway activity scoring and differential activity analysis for each cell type to identify pathways significantly altered in ASD compared to control