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During nocturnal hours, when mice are normally present, those lacking orexin demonstrated murine cataplexy and displayed brain and muscle electrical activity similar to the activity present during REM and NREM sleep

CMR acquisition and analysis All patients underwent a CMR scan to evaluate left ventricular (LV) volumes, mass, systolic and diastolic function and scar tissue

Western Blotting The protein levels of dynamin-related protein (Drp)-1, fission protein (Fis)-1, phosphatase and tensin homolog induced putative kinase (Pink)-1, Parkin, optic atrophy (Opa)-1, light chain 3 microtubule-associated protein A/B (LC3A/B), manganese superoxide dismutase (MnSOD), translocase of outer membrane (Tom)-20 and OXPHOS complexes were measured by western blotting

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