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Some animal and early-phase studies noted elevated inflammatory cytokines (IL-6, TNF-) at higher doses, though clinical relevance in humans at therapeutic doses remains unclear

It serves a different function in the metabolic architecture and is often most effective as part of a combined protocol

Ultimately, unmitigated oxidant stress contributes to increased fatty acid desaturation, oxidation and migration to the membrane of oxidized proteins (e.g., peroxiredoxin 2 [34]), vesiculation of oxidized proteins [12] and lipids [164], a process that promotes the loss of the RBC discocytic phenotype and the acquisition of an echinocytic, spheroechinocytic and spherocytic morphology [141,143,165,166]

Biomed Pharmacother 2001;55:38190