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The following grades were used to determine the macroscopic score: 0 for non-visible changes,1 for mild erythema and mucosal edema or erosion, 2 for moderate edema, bleeding, or erosion, and 3 for severe edema, ulcers, or necrosis

Taken together, our results clearly demonstrated that a higher level of estrogen in female Keap1 cKO mice further stabilizes Nrf2 protein by inactivating the GSK3-dependent degradation pathway

Superoxide radical, if not scavenged effectively, may directly inactivate several enzymes like CAT and GPx which are needed to eliminate hydrogen peroxide from intracellular medium

In an open-label RCT ( n = 96), oral administration of melatonin tablets (3 mg/d, 1 h before sleep, for 7 days) with standard treatment, substantially improved sleep quality and blood O 2 saturation parameters in hospitalized COVID-19 patients 667