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Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts

Two ongoing phase I, randomized, double-blind, placebo-controlled trials are ongoing and aim to evaluate safety, tolerability and target engagement of DNL151 in healthy volunteers (NCT04557800) and PD patients (NCT04056689)

This reaction results from tissue disruption and typically resolves within hours

Another potential risk factor that may be present in an increasing number of patients is hepatic steatosis or steatohepatitis caused by obesity, type 2 diabetes, and poor diet [180]