acetaminophen deplete glutathione mechanism The Metabolism of and the Synthesis of Current concepts of experimental acetaminophen
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Two cytosolic enzymes, GCLC/-GCS (glutamate-cysteine ligase catalytic subunit) and GSS (glutathione synthetase), sequentially catalyze the synthesis of GSH from glycine, cysteine and glutamate in the presence of adenosine 5-triphosphate/ATP (Figure 3) [84]
Miess, H
doi: 10.1016/S1672-6308(11)60026-7 150 ZhouY.StaatzJ
