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17 Obesity Obesity is a major contributing factor for CKD, explained in part by the observation that obesity predisposes individuals to diabetes and hypertension

In breast cancer, RNF5 loss is associated with increased ASCT2 expression, finally leading to poor patient outcomes, and poor response to paclitaxel (Ma et al., 2021), colon cancer (Ma et al., 2018), pancreatic cancer (Wang et al., 2022), and TNBC (Van Geldermalsen et al., 2016)

S., Henkel C., Svensson R

Unfortunately, the studies investigating the differential, temporal expression of EAATs in NP models were mostly conducted in male rodents, so the relationship between EAAT expression, the induction and maintenance of NP, and sex differences, are not well understood