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2122, Supplementary Note 3)

Conversely, dietary changes that restore balance to the gut microbiota can improve lipid metabolism through the aforementioned mechanisms ( 2.4 NAFLD Dietary adjustments have been proven to be a highly effective approach in controlling and mitigating NAFLD ( Improving the quality of diet, reducing the consumption of pro-inflammatory foods, and increasing the intake of anti-inflammatory foods are potential dietary interventions to reduce the risk of NAFLD ( de novo lipogenesis (DNL) and fasting insulin (71)

As a triple agonist , it simultaneously activates three distinct receptor systems [5]: GIP (Glucose-dependent Insulinotropic Polypeptide) receptors enhance insulin secretion and may have direct effects on adipose tissue GLP-1 (Glucagon-like Peptide-1) receptors promote satiety, slow gastric emptying, and improve glucose regulation Glucagon receptors increase energy expenditure and may enhance fat oxidation This multi-receptor targeting strategy distinguishes retatrutide from single-pathway peptides and creates a complex metabolic profile that researchers are still working to fully characterize

& Major-Pedersen, A