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Fortunately, they were able to knock that on the head quite quickly, something that non clinicians find more challenging to do

Yet the consequences are unknown Bioavailability: there are four specific metabolic steps necessary to convert cyanocobalamin into one of the coenzyme forms, which is a clear metabolic disadvantage (3) Utilisation problems: certain hereditary diseases, as well as metabolic disorders, prevent the conversion of cyanocoalamin into the active B12 forms (4) Steals methyl groups: cyanocobalamin requires a methyl group to convert into methylcobalamin, which it takes from the important amino acid S-adenosylmethionine (SAM)

In some cases, high-dose daily oral B12 supplements (typically 1000 g daily) can also be used as an effective alternative or addition for maintenance therapy [9] [10]

A reader is best served by holding two things at once: the mechanism is genuinely interesting, and the human evidence does not yet exist