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Some patients feel as though they want more frequent injections, and occasionally we test levels to see if they are receiving adequate replacement, but Im not sure how strong the evidence is to support this. GPs should consider periodic vitamin B12 testing of higher-risk patients who take metformin, even if they dont display symptoms of deficiency, the UK medicines regulator said earlier this year

The "MDCT" Combination Protocol Study (2025) This is a very recent study investigating a high-delivery method (microneedling/micro-infusion) using copper peptides as a synergistic agent alongside traditional supplements

It also allows for personalized treatment that suits the individual

Draw the medicine from the vial using one needle