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While retreatment with a platinum-based regimen is reasonable after a six month platinum-free period, resistance is common and may be attributed to increased IGF-1R expression in ovarian tumor cells [120]

Arachidonic acid metabolism The lipid arachidonic acid (AA) is a major component of cell membranes, is a PUFA and is primarily metabolized by three families of enzymes: by PTGS1/COX (prostaglandin-endoperoxide synthase 1) to form prostaglandins and thromboxanes, by ALOX to form leukotrienes, and by CYP (cytochrome P450 family) enzymes to form epoxides [89]

Clinical Efficacy of Moringa oleifera Lam

[DOI] [Google Scholar] Kelly R