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In line with these findings, prior work showed that E2 heightens the inflammatory response to ip injection of thioglycollate or lipopolysaccharide (291), and that ER is critical not only in mediating these actions but also for reducing bacterial burden through phagocytosis

Multi-scale, multi-level anisotropic silk fibroin/metformin scaffolds for repair of peripheral nerve injury

doi: 10.1038/oby.2011.256

At the molecular level, SRA directly bound Notch1 and suppressed its GS-ylation, thereby inhibiting the Notch pathway activation [112]