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Accordingly, future studies may require combined strategies, such as CRISPR-mediated introduction of PD-associated mutations with targeted knock-in of progeric factors (for example, I-PpoI 93 , Trf2 94 or LMNA variants 95 ) to accelerate cellular aging in hPS cell-derived DA neurons

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Probing the Presumed Catalytic Triad of Selenium-Containing Peroxidases by Mutational Analysis of Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx) Biol

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