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Annu Rev Neurosci 24:10711089 [DOI] [PubMed] [Google Scholar] Zeng Y, Lv F, Li L, Yu H, Dong M, Fu Q
Senescent cells are known for their pro-inflammatory secretory phenotype, termed the Senescence-Associated Secretory Phenotype (SASP), which FOXO4-DRI effectively reduces, improving tissue function
Subcutaneous injection is the most common research-context format today, but no published human pharmacokinetic study has formally characterized subcutaneous AOD-9604 (this gap was specifically called out in FDA's December 2024 review)
